These lists is a must for every scientist

PLoS Computational Biology have a great ten simple rule series covering everything from how to make a good oral presentation, to how to select a postdoctoral position. These lists is a must for every scientist.

And here are my ten best picks from the complete 60 simple rules:

    Sell Your Work in Ten Seconds

    Some conferences will present hundreds of posters; you will need to fight for attention. The first impressions of your poster, and to a lesser extent what you might say when standing in front of it, are crucial. It is analogous to being in an elevator and having a few seconds to peak someone’s interest before they get off. The sad truth is that you have to sell your work. One approach is to pose your work as addressing a decisive question, which you then address as best you can. Once you have posed the question, which may well also be the motivation for the study, the focus of your poster should be on addressing that question in a clear and concise way.

    Less is More

    A common mistake of inexperienced presenters is to try to say too much. They feel the need to prove themselves by proving to the audience that they know a lot. As a result, the main message is often lost, and valuable question time is usually curtailed. Your knowledge of the subject is best expressed through a clear and concise presentation that is provocative and leads to a dialog during the question-and-answer session when the audience becomes active participants. At that point, your knowledge of the material will likely become clear. If you do not get any questions, then you have not been following the other rules. Most likely, your presentation was either incomprehensible or trite. A side effect of too much material is that you talk too quickly, another ingredient of a lost message.

    Read many papers, and learn from both the good and the bad work of others.

    It is never too early to become a critic. Journal clubs, where you critique a paper as a group, are excellent for having this kind of dialogue. Reading at least two papers a day in detail (not just in your area of research) and thinking about their quality will also help. Being well read has another potential major benefit—it facilitates a more objective view of one’s own work. It is too easy after many late nights spent in front of a computer screen and/or laboratory bench to convince yourself that your work is the best invention since sliced bread. More than likely it is not, and your mentor is prone to falling into the same trap.

    Start writing the paper the day you have the idea of what questions to pursue.

    Some would argue that this places too much emphasis on publishing, but it could also be argued that it helps define scope and facilitates hypothesis-driven science. The temptation of novice authors is to try to include everything they know in a paper. Your thesis is/was your kitchen sink. Your papers should be concise, and impart as much information as possible in the least number of words. Be familiar with the guide to authors and follow it, the editors and reviewers do. Maintain a good bibliographic database as you go, and read the papers in it.

    Remember, Reviewers Are People, Too

    Typically, reviewers will have a large number of grants to review in a short period. They will easily lose concentration and miss key points of your proposal if these are buried in an overly lengthy or difficult-to-read document. Also, more than likely, not all the reviewers will be experts in your discipline. It is a skill to capture the interest of experts and nonexperts alike. Develop that skill. Unlike a paper, a grant provides more opportunity to apply literary skills. Historical perspectives, human interest, and humor can all be used judiciously in grants to good effect. Use formatting tricks , for example, underlining, bolding, etc., and restate your key points as appropriate. Each section can start with a summary of the key points.

    Select a Position that Excites You

    If you find the position boring, you will not do your best work—believe us, the salary will not be what motivates you, it will be the science. Discuss the position fully with your proposed mentor, review the literature on the proposed project, and discuss it with others to get a balanced view. Try and evaluate what will be published during the process of your research. Being scooped during a postdoc can be a big setback. Just because the mentor is excited about the project does not mean you that will be six months into it.

    Select a Laboratory That Suits Your Work and Lifestyle

    If at all possible, visit the laboratory before making a decision. Laboratories vary widely in scope and size. Think about how you like to work—as part of a team, individually, with little supervision, with significant supervision (remembering that this is part of your training where you are supposed to be becoming independent), etc. Talk to other graduate students and postdoctoral fellows in the laboratory and determine the work style of the laboratory. Also, your best work is going to be done when you are happiest with the rest of your life. Does the location of the laboratory and the surrounding environment satisfy your nonwork interests?

    Learn to Recognize Opportunities

    New areas of science emerge and become hot very quickly. Getting involved in an area early on has advantages, since you will be more easily recognized. Consider a laboratory and mentor that have a track record in pioneering new areas or at least the promise to do so.

    Do Not Be Lured into Just Any Collaboration

    Learn to say no, even if it is to an attractive grant that would involve significant amounts of money and/or if it is a collaboration with someone more established and well-known. It is easier to say no at the beginning—the longer an ill-fated collaboration drags on, the harder it is to sever, and the worse it will be in the end. Enter a collaboration because of a shared passion for the science, not just because you think getting that grant or working with this person would look good on your curriculum vitae. Attending meetings is a perfect opportunity to interact with people who have shared interests. Take time to consider all aspects of the potential collaboration. Ask yourself, will this collaboration really make a difference in my research? Does this grant constitute a valid motivation to seek out that collaboration? Do I have the expertise required to tackle the proposed tasks? What priority will this teamwork have for me? Will I be able to deliver on time? If the answer is no for even one of these questions, the collaboration could be ill-fated.

    Make the Take-Home Message Persistent

    A good rule of thumb would seem to be that if you ask a member of the audience a week later about your presentation, they should be able to remember three points. If these are the key points you were trying to get across, you have done a good job. If they can remember any three points, but not the key points, then your emphasis was wrong. It is obvious what it means if they cannot recall three points!

Guide To The Graduate Position You Want

Shelley Batts at Retrospectable has compiled a very nice guide
what to think about to improve your chances of getting into graduate school. This is recommended reading for everyone who is about to apply for graduate school in sciences. A thing to remember though, as also taken up in the comments to her post, is that you don’t need to do everything on the list to actually get a good position.

Maybe the most important of all on her guide is that “good scientists don’t always make good mentors” and “don’t be afraid to get out if it isn’t working”. These are key issues and a good personality match to the lab, supervisor and area is the absolute most important thing to succeed with your graduate studies. Far too many times, students choose a lab based solely on hype and not at all based on how you will “like” the lab and where it might take you in the future. Remember that great discoveries not always comes from the current top labs swimming around in funding, but from smaller less noticed labs with less funding. This is a point where I feel I might not completely agree with Shelley Batts views, but ending up in a lab that is totally academically broke could of course be deadly. Just do your research before choosing and you should be fine.

Tips For Struggling PhD Students

We all need help and guidance in our life. As scientists maybe even more so when “failure” is a part of everyday work. It takes a strong psyche to rigorously plan and execute an experiment just to, after a week of painstaking work, realize that an antibody didn’t work as expected or the perfect hypothesis was proven wrong. Is it getting to you? Read on and get back on track again.

Failure in the lab can be divided up into three areas:

  • A completely hopeless project
  • Asking the wrong questions
  • Poor experimental design

Being involved in a big, completely hopeless project might be the trickiest part to fix, since other people working on the same project might not share your views. The only thing you can do is to try to convince your co-workers or supervisor that a new line of action is needed based on the results you have. Not an easy task for someone on the bottom of the food chain.

The second area, although coupled to the first, is more how you formulate your questions and hypotheses in your own sub-projects. This is the key to all science and, as can be read in the article cited below, the thing that separates a good creative scientist from a mediocre one. Even though this can be improved by knowing your field, it is just as important to widen your horizons, reading tons of articles in other fields to boost creativity. Of course there is also a great deal of talent involved in asking the correct questions, but with training you can definitely get better at it.

Experimental failure can always be minimized by good experimental design. Far to many times I have myself started an experiment without thinking it through properly; to the utter dismay of my supervisor, when he sees the non-existing results. If you feel you might have a problem in this area I highly recommend reading an article by Tung-Tien Sun called: Excessive trust in authorities and its influence on experimental design, published in Molecular Cell Biology. In the article, he describes key concepts of good experimental design, covering areas such as risk assessment, good note-taking and a thorough understanding of protocols as well as the influence of authorities.

If everything still feel hopeless even after practicing on the issues above you should read the article: Mastering Your PhD: Dealing with Setbacks at Science Careers by Patricia Gosling and Bart Noordam.

Good Luck

The Grinding Science

“Molecular biology was routine. It required no creativity, no imagination and only the most basic secondary intellect……
…….It’s like following a recipe. From time to time someone comes up with better equipment and they give him the Nobel prize. It’s a joke.”

The quote above is from the book Atomised written by Michel Houellebecq and should piss me off big-time but unfortunately I think it portraits the dark truth of biomedical science. Instead of being creative, trying out new hypotheses and taking risks, many scientists put down their energy and resources in projects that are “safe”. Although it might be necessary, where is the beauty, and science for that matter, in cloning gene number one and then repeating the exact same procedure for gene number two?

This might be extreme but definitely worth giving a thought and I wonder how much valuable funding money is drained by scientist just grinding their day away.

It all boils down to what can be read in the footer of Science Blog: “Think. It’s not illegal yet”

Key Posts Regarding Open Science

Bill Hooker over at 3quarks daily has written the three essays below on open science, and if you haven’t read them before and you are interested in the open science movement I highly recommend you to do so. The three posts contain tons of links to other posts regarding open science and is a good starting point if you are interested in the subject.

The Future of Science is Open, Part 1: Open Access.

The Future of Science is Open, Part 2: Open Science

The Future of Science is Open, Part 3: An Open Science World

Make A Gummy Bear Double Helix

Want to do something useful whit your gummy bears next time you buy them instead of just indulging. Why not try to build a double helix using the scheme from YourGenome below.

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Buffer Calculator

Do you spend a lot of time at the pH-meter adding drop by drop of your acid or base to get a certain pH?
Don´t worry! We have the solution.

We have now added a buffer calculator which can be used for calculating the amount of acid or base to add to your buffer to get the pH you want in no time at all. The calculator is still a work in progress and will soon be updated with more features.

Enjoy

The Interpreters of Genesis and the Interpreters of Nature

“The antagonism between science and religion, about which we hear so much, appears to me to be purely factitious–fabricated, on the one hand, by short-sighted religious people who confound a certain branch of science, theology, with religion; and, on the other, by equally short-sighted scientific people who forget that science takes for its province only that which is susceptible of clear intellectual comprehension; and that, outside the boundaries of that province, they must be content with imagination, with hope, and with ignorance.”

T. H. Huxley - The Interpreters of Genesis and the Interpreters of Nature (1885)

Three Pictures With One Concept

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DNA 11 produces and sells personalized art based on your own DNA and fingerprints.

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This is the DNA stair designed by Geoffrey Packer who specializes in experimental 3D design.

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This picture is a nice summary of the two above.

Speeding up delivery times – An Old Drug Reinvented

Heparin, one of the oldest drugs still in use in the clinic (discovered in 1916) has found a new application area. A modified non-anticoagulant heparin might soon be the drug of choice for the “latte-mommy” to be.

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By pixnpics on Flickr

According to statistics from the website of Dilafor, the company which develops the drug, 50% of all deliveries in the developed world show a slow progress. This poses a great risk for both the child and mother since in 10-25% of these cases result in emergency intervention, such as cesarean section. Today, slow progress of labor is augmented by the use of oxytocin.

The idea for the use of heparin to treat protracted labor was incidental and came from the clinic, where pregnant women where treated with low molecular weight heparin to reduce the risk of developing thrombosis. What could be seen was that women who were given the anticoagulant heparin had less prolonged delivery time than women that hadn’t been treated.
The problem with the low molecular weight heparin though is that it is anticoagulant and could increase the risk of bleeding during delivery. Researchers at Dilafor has solved this problem by producing a chemically modified heparin that doesn’t have anticoagulant activity but that in experiments has been shown to retain the effect on uterus and cervix tissue.

The drug that they have named, DF01 has in Sweden gone through Phase 1 studies on healthy volunteers during 2006, and has in March gone in to Phase 2 clinical trials on patients.

Latte-Mommy: The modern social mom that can be found at the closest trendy café with a Café Latte in their hands.